The MNU Plus Testosterone Rat Model of Prostate Carcinogenesis.

ABSTRACT: Animal models of prostate cancer are essential to identify chemopreventive treatments against this major male malignancy. The N-methyl-N-nitrosourea (MNU) plus testosterone rat model of prostate carcinogenesis is a reliable animal model that recapitulates human prostate cancer in many respects and has been used extensively in chemoprevention studies with good predictive value for the results of human clinical trials. The objective of this article is to describe the induction protocol of this model, demonstrate its robustness and reproducibility over time and across rat strains, provide diagnostic criteria for the identification of prostate lesions, and present the current tumor induction protocol so that others can use this model in a reliable manner. The majority of accessor

SUBMITTER: Bosland MC 

PROVIDER: S-EPMC9347216 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature