Plasminogen activator inhibitor-1 promoter sequence variations in idiopathic osteonecrosis of head of femur.

ABSTRACT:

Background & objectives

Primary or idiopathic osteonecrosis of femur head (ONFH) is the second most commonly observed cause among Indian patients suffering from ischemic ONFH. Although a number of genetic polymorphisms have been associated with idiopathic ONFH pathogenesis in Korean and Chinese populations, there are no studies in the Indian population. This is an exploratory study designed to implicate in promoter sequence polymorphisms of a critical fibrinolytic system regulator, plasminogen activator inhibitor-1 (PAI-1) gene, in cases of idiopathic osteonecrosis. Promoter sequence variations can affect expression levels of PAI-1 gene and may disrupt the coagulation/fibrinolytic equilibrium, which may finally culminate into osteonecrosis. Hence, the aim of the study was to invest

SUBMITTER: Raman S 

PROVIDER: S-EPMC9347242 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature