Dynamic Classification of Plasmodium vivax Malaria Recurrence: An Application of Classifying Unknown Cause of Failure in Competing Risks.

ABSTRACT: A standard competing risks set-up requires both time to event and cause of failure to be fully observable for all subjects. However, in application, the cause of failure may not always be observable, thus impeding the risk assessment. In some extreme cases, none of the causes of failure is observable. In the case of a recurrent episode of Plasmodium vivax malaria following treatment, the patient may have suffered a relapse from a previous infection or acquired a new infection from a mosquito bite. In this case, the time to relapse cannot be modeled when a competing risk, a new infection, is present. The efficacy of a treatment for preventing relapse from a previous infection may be underestimated when the true cause of infection cannot be classified. In this paper, we developed a no

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9347664 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature