COVID-19 Infection Enhances Susceptibility to Oxidative Stress-Induced Parkinsonism.

ABSTRACT:

Background

Viral induction of neurological syndromes has been a concern since parkinsonian-like features were observed in patients diagnosed with encephalitis lethargica subsequent to the 1918 influenza pandemic. Given the similarities in the systemic responses after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with those observed after pandemic influenza, there is a question whether a similar syndrome of postencephalic parkinsonism could follow coronavirus disease 2019 infection.

Objective

The goal of this study was to determine whether prior infection with SARS-CoV-2 increased sensitivity to a mitochondrial toxin known to induce parkinsonism.

Methods

K18-hACE2 mice were infected with SARS-CoV-2 to induce mild-to-moderate disease. After 38 d

SUBMITTER: Smeyne RJ 

PROVIDER: S-EPMC9347874 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature