Mechanistic insights of key host proteins and potential repurposed inhibitors regulating SARS-CoV-2 pathway.

ABSTRACT: The emergence of pandemic situations originated from severe acute respiratory syndrome (SARS)-CoV-2 and its new variants created worldwide medical emergencies. Due to the non-availability of efficient drugs and vaccines at these emergency hours, repurposing existing drugs can effectively treat patients critically infected by SARS-CoV-2. Finding a suitable repurposing drug with inhibitory efficacy to a host-protein is challenging. A detailed mechanistic understanding of the kinetics, (dis)association pathways, key protein residues facilitating the entry-exit of the drugs with targets are fundamental in selecting these repurposed drugs. Keeping this target as the goal of the paper, the potential repurposing drugs, Nafamostat, Camostat, Silmitasertib, Valproic acid, and Zotatifin with host-pr

SUBMITTER: Pramanik D 

PROVIDER: S-EPMC9348233 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature