Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization.

ABSTRACT: Mendelian Randomisation (MR) is a powerful tool in epidemiology that can be used to estimate the causal effect of an exposure on an outcome in the presence of unobserved confounding, by utilising genetic variants as instrumental variables (IVs) for the exposure. The effect estimates obtained from MR studies are often interpreted as the lifetime effect of the exposure in question. However, the causal effects of some exposures are thought to vary throughout an individual's lifetime with periods during which an exposure has a greater effect on a particular outcome. Multivariable MR (MVMR) is an extension of MR that allows for multiple, potentially highly related, exposures to be included in an MR estimation. MVMR estimates the direct effect of each exposure on the outcome conditional on all t

SUBMITTER: Sanderson E 

PROVIDER: S-EPMC9348730 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature