Sensitivity and specificity of microRNA-204, CA125, and CA19.9 as biomarkers for diagnosis of ovarian cancer.

ABSTRACT:

Background

Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for detecting ovarian cancer are urgently needed.

Objective

This study aimed to investigate the efficacy of six biomarkers for the early clinical diagnosis of ovarian cancer.

Subjects & methods

The study included 120 patients (benign ovarian tumors and early and late ovarian carcinoma) and 30 control healthy volunteers. MiRNA-204, CA125, CA19.9, hepcidin, microfibril-associated glycoprotein 2, and ferroportin levels were determined in all patients and control volunteers.

Results

The combined area under the receiver operating characteristic curves for miRNA-204, CA125, and CA19.9 were 0.938, 1.000, a

SUBMITTER: Ali FT 

PROVIDER: S-EPMC9348731 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature