Prolactin at moderately increased levels confers a neuroprotective effect in non-secreting pituitary macroadenomas.

ABSTRACT:

Context

Prolactin, a hormone synthesized by the anterior pituitary gland demonstrates promise as a neuroprotective agent, however, its role in humans and in vivo during injury is not fully understood.

Objective

To investigate whether elevated levels of prolactin attenuate injury to the retinal nerve fiber layer (RNFL) following compression of the optic chiasm in patients with a prolactin secreting pituitary macroadenoma (i.e., prolactinoma).

Design setting and participants

A retrospective cross-sectional study of all pituitary macroadenoma patients treated at a single institution between 2009 and 2019.

Main outcome measure(s)

Primary outcome measures included RNFL thickness, mean deviation, and prolactin levels for both prolactin-secreting and non-secreting pit

SUBMITTER: Paul DA 

PROVIDER: S-EPMC9348739 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature