Effect of combustion particle morphology on biological responses in a Co-culture of human lung and macrophage cells.

ABSTRACT: Atmospheric aging of combustion particles alters their chemical composition and morphology. Previous studies have reported differences in toxicological responses after exposure to fresh versus aged particles, with chemical composition being the prime suspect behind the differences. However, less is known about the contribution of morphological differences in atmospherically aged particles to toxicological responses, possibly due to the difficulty in resolving the two properties (composition and morphology) that change simultaneously. This study altered the shape of lab-generated combustion particles, without affecting the chemical composition, from fractal-like to a more compact spherical shape, using a water condensation-evaporation method. The two shapes were exposed to a co-culture of h

SUBMITTER: Kaur K 

PROVIDER: S-EPMC9348743 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature