Mural Cell SRF Controls Pericyte Migration, Vessel Patterning and Blood Flow.

ABSTRACT:

Background

Pericytes and vascular smooth muscle cells, collectively known as mural cells, are recruited through PDGFB (platelet-derived growth factor B)-PDGFRB (platelet-derived growth factor receptor beta) signaling. MCs are essential for vascular integrity, and their loss has been associated with numerous diseases. Most of this knowledge is based on studies in which MCs are insufficiently recruited or fully absent upon inducible ablation. In contrast, little is known about the physiological consequences that result from impairment of specific MC functions. Here, we characterize the role of the transcription factor SRF (serum response factor) in MCs and study its function in developmental and pathological contexts.

Methods

We generated a mouse model of MC-specific inducible

SUBMITTER: Orlich MM 

PROVIDER: S-EPMC9348820 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature