Robust and Efficient Assessment of Potency (REAP) as a quantitative tool for dose-response curve estimation.

ABSTRACT: The median-effect equation has been widely used to describe the dose-response relationship and identify compounds that activate or inhibit specific disease targets in contemporary drug discovery. However, the experimental data often contain extreme responses, which may significantly impair the estimation accuracy and impede valid quantitative assessment in the standard estimation procedure. To improve the quantitative estimation of the dose-response relationship, we introduce a novel approach based on robust beta regression. Substantive simulation studies under various scenarios demonstrate solid evidence that the proposed approach consistently provides robust estimation for the median-effect equation, particularly when there are extreme outcome observations. Moreover, simulation studies i

SUBMITTER: Zhou S 

PROVIDER: S-EPMC9348845 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature