Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity.

ABSTRACT: The emergence of SARS-CoV-2 variants with mutations in major neutralizing antibody-binding sites can affect humoral immunity induced by infection or vaccination^1-6. Here we analysed the development of anti-SARS-CoV-2 antibody and T cell responses in individuals who were previously infected (recovered) or uninfected (naive) and received mRNA vaccines to SARS-CoV-2. While individuals who were previously infected sustained higher antibody titres than individuals who were uninfected post-vaccination, the latter reached comparable levels of neutralization responses to the ancestral strain after the second vaccine dose. T cell activation markers measured upon spike or nucleocapsid peptide in vitro stimulation showed a progressive increase after vaccination. Comprehensive analysis of p

SUBMITTER: Lucas C 

PROVIDER: S-EPMC9348899 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature