Architecture of the cytoplasmic face of the nuclear pore.
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ABSTRACT:
SUBMITTER: Bley CJ
PROVIDER: S-EPMC9348906 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Publications
Architecture of the cytoplasmic face of the nuclear pore.
Bley Christopher J CJ Nie Si S Mobbs George W GW Petrovic Stefan S Gres Anna T AT Liu Xiaoyu X Mukherjee Somnath S Harvey Sho S Huber Ferdinand M FM Lin Daniel H DH Brown Bonnie B Tang Aaron W AW Rundlet Emily J EJ Correia Ana R AR Chen Shane S Regmi Saroj G SG Stevens Taylor A TA Jette Claudia A CA Dasso Mary M Patke Alina A Palazzo Alexander F AF Kossiakoff Anthony A AA Hoelz André A
Science (New York, N.Y.) 20220610 6598
INTRODUCTION The subcellular compartmentalization of eukaryotic cells requires selective transport of folded proteins and protein-nucleic acid complexes. Embedded in nuclear envelope pores, which are generated by the circumscribed fusion of the inner and outer nuclear membranes, nuclear pore complexes (NPCs) are the sole bidirectional gateways for nucleocytoplasmic transport. The ~110-MDa human NPC is an ~1000-protein assembly that comprises multiple copies of ~34 different proteins, collectivel ...[more]
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