Hemodynamic and Geometric Risk Factors for In-Stent Restenosis in Patients with Intracranial Atherosclerotic Stenosis

ABSTRACT:

Methods

Severe ICAS patients managed with percutaneous transluminal angioplasty and stenting (PTAS) were included in the retrospective cohort study and were divided into two groups according to whether ISR occurred at follow-up (ISR group and no-ISR group). Computational fluid dynamics models were built based on digital subtraction angiography before and after PTAS to simulate blood flow and quantify hemodynamic parameters. The associations between vessel geometry, hemodynamics, and ISR in ICAS patients were investigated.

Results

Among 39 patients, ISR occurred in seven patients (17.95%) after a mean follow-up period of 6.69 ± 3.24 months. Stenting decreased vessel angulation (51.11° [40.07°–67.27°] vs. 15.97° [0.00°–36.16°], P = 0.000) and vessel tortuosity (0.09 [0.06

SUBMITTER: Song X 

PROVIDER: S-EPMC9348934 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature