Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children.

ABSTRACT:

Background

Glycine is a proteogenic amino acid that is required for numerous metabolic pathways, including purine, creatine, heme, and glutathione biosynthesis. Glycine formation from serine, catalyzed by serine hydroxy methyltransferase, is the major source of this amino acid in humans. Our previous studies in a mouse model have shown a crucial role for the 10-formyltetrahydrofolate dehydrogenase enzyme in serine-to-glycine conversion.

Objectives

We sought to determine the genomic influence on the serine-glycine ratio in 803 Hispanic children from 319 families of the Viva La Familia cohort.

Methods

We performed a genome-wide association analysis for plasma serine, glycine, and the serine-glycine ratio in Sequential Oligogenic Linkage Analysis Routines while accountin

SUBMITTER: Krupenko SA 

PROVIDER: S-EPMC9348975 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature