Breastfeeding duration modifies the association between maternal weight status and offspring dietary palmitate oxidation.

ABSTRACT:

Background

Offspring of obese rodents develop a metabolic phenotype that favors fat deposition. Data regarding the impact of maternal obesity programing of offspring fuel usage in humans is scarce.

Objective

The objective of this study was to explore the association between maternal weight status and dietary palmitate oxidation (DPO) in 2-y-old offspring, taking into consideration potential confounders and modifiers.

Methods

Women (n = 56) were enrolled by the first trimester of gestation. Maternal physical activity (PA; measured with accelerometers) at enrollment and gestational weight gain (GWG) were measured. Offspring sex, race, and breastfeeding (BF) duration were self-reported. Human milk (HM) composition was determined at 6 mo postpartum. At age 2 y, dietary qu

SUBMITTER: Diaz EC 

PROVIDER: S-EPMC9348976 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature