Vitamin D and brain health: an observational and Mendelian randomization study.

ABSTRACT:

Background

Higher vitamin D status has been suggested to have beneficial effects on the brain.

Objectives

To investigate the association between 25-hydroxyvitamin D [25(OH)D], neuroimaging features, and the risk of dementia and stroke.

Methods

We used prospective data from the UK Biobank (37-73 y at baseline) to examine the association between 25(OH)D concentrations with neuroimaging outcomes (N = 33,523) and the risk of dementia and stroke (N = 427,690; 3414 and 5339 incident cases, respectively). Observational analyses were adjusted for age, sex, ethnicity, month, center, and socioeconomic, lifestyle, sun behavior, and illness-related factors. Nonlinear Mendelian randomization (MR) analyses were used to test for underlying causality for neuroimaging outcomes (N = 23

SUBMITTER: Navale SS 

PROVIDER: S-EPMC9348994 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature