A prognostic model of acute-on-chronic liver failure based on sarcopenia.

ABSTRACT:

Background

Acute-on-chronic liver failure (ACLF) is characterized by the development of a syndrome associated with a high risk of short-term death in patients with acute decompensated cirrhosis, and better indicators are needed to predict such outcomes. Sarcopenia, a common complication of cirrhosis, is closely associated with poor prognosis and increased mortality. In this study, the skeletal muscle index of ACLF patients was measured to determine whether sarcopenia combined with clinical parameters can aid in identifying those at high risk of progression.

Methods

A total of 433 hospitalized patients with ACLF according to the APASL criteria were included and allocated into two groups: transplantation-free survival (n = 293) or progression (n = 140, 107 died; 33 underwent l

SUBMITTER: Peng H 

PROVIDER: S-EPMC9349113 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature