Preferences for return of germline genome sequencing results for cancer patients and their genetic relatives in a research setting.

ABSTRACT: Germline genome sequencing (GS) holds great promise for cancer prevention by identifying cancer risk and guiding prevention strategies, however research evidence is mixed regarding patient preferences for receiving GS results. The aim of this study was to discern preferences for return of results by cancer patients who have actually undergone GS. We conducted a mixed methods study with a cohort of cancer probands (n = 335) and their genetic relatives (n = 199) undergoing GS in a research setting. Both groups completed surveys when giving consent. A subset of participants (n = 40) completed semi-structured interviews. A significantly higher percentage of probands thought people would like to be informed about genetic conditions for which there is prevention or treatment that can change canc

SUBMITTER: Best MC 

PROVIDER: S-EPMC9349221 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature