Plasticity of body axis polarity in Hydra regeneration under constraints.

ABSTRACT: One of the major events in animal morphogenesis is the emergence of a polar body axis. Here, we combine classic grafting techniques with live imaging to explore the plasticity of polarity determination during whole body regeneration in Hydra. Composite tissues are made by fusing two rings, excised from separate animals, in different configurations that vary in the polarity and original positions of the rings along the body axes of the parent animals. Under frustrating initial configurations, body axis polarity that is otherwise stably inherited from the parent animal, can become labile and even be reversed. Importantly, the site of head regeneration exhibits a strong bias toward the edges of the tissue, even when this involves polarity reversal. In particular, we observe head formation at

SUBMITTER: Livshits A 

PROVIDER: S-EPMC9349251 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature