Epigenetic signatures relating to disease-associated genotypic burden in familial risk of bipolar disorder.

ABSTRACT: Environmental factors contribute to risk of bipolar disorder (BD), but how environmental factors impact the development of psychopathology within the context of elevated genetic risk is unknown. We herein sought to identify epigenetic signatures operating in the context of polygenic risk for BD in young people at high familial risk (HR) of BD. Peripheral blood-derived DNA was assayed using Illumina PsychArray, and Methylation-450K or -EPIC BeadChips. Polygenic risk scores (PRS) were calculated using summary statistics from recent genome-wide association studies for BD, major depressive disorder (MDD) and cross-disorder (meta-analysis of eight psychiatric disorders). Unrelated HR participants of European ancestry (n = 103) were stratified based on their BD-PRS score within the HR-population

SUBMITTER: Hesam-Shariati S 

PROVIDER: S-EPMC9349272 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature