Virology and immune dynamics reveal high household transmission of ancestral SARS-CoV-2 strain.

ABSTRACT:

Background

Household studies are crucial for understanding the transmission of SARS-CoV-2 infection, which may be underestimated from PCR testing of respiratory samples alone. We aim to combine the assessment of household mitigation measures; nasopharyngeal, saliva, and stool PCR testing; along with mucosal and systemic SARS-CoV-2-specific antibodies, to comprehensively characterize SARS-CoV-2 infection and transmission in households.

Methods

Between March and September 2020, we obtained samples from 92 participants in 26 households in Melbourne, Australia, in a 4-week period following the onset of infection with ancestral SARS-CoV-2 variants.

Results

The secondary attack rate was 36% (24/66) when using nasopharyngeal swab (NPS) PCR positivity alone. However, when res

SUBMITTER: Tosif S 

PROVIDER: S-EPMC9349415 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature