Alterations in CD39/CD73 axis of T cells associated with COVID-19 severity.

ABSTRACT: Purinergic signaling modulates immune function and is involved in the immunopathogenesis of several viral infections. This study aimed to investigate alterations in purinergic pathways in coronavirus disease 2019 (COVID-19) patients. Mild and severe COVID-19 patients had lower extracellular adenosine triphosphate and adenosine levels, and higher cytokines than healthy controls. Mild COVID-19 patients presented lower frequencies of CD4⁺ CD25⁺ CD39⁺ (activated/memory regulatory T cell [mTreg]) and increased frequencies of high-differentiated (CD27^- CD28^- ) CD8⁺ T cells compared with healthy controls. Severe COVID-19 patients also showed higher frequencies of CD4⁺ CD39⁺ , CD4⁺ CD25^- C

SUBMITTER: Dorneles GP 

PROVIDER: S-EPMC9349448 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature