Uncovering the genetic links of SARS-CoV-2 infections on heart failure co-morbidity by a systems biology approach.

ABSTRACT:

Aims

The co-morbidities contribute to the inferior prognosis of COVID-19 patients. Recent reports suggested that the higher co-morbidity rate between COVID-19 and heart failure (HF) leads to increased mortality. However, the common pathogenic mechanism between them remained elusive. Here, we aimed to reveal underlying molecule mechanisms and genetic correlation between COVID-19 and HF, providing a new perspective on current clinical management for patients with co-morbidity.

Methods

The gene expression profiles of HF (GSE26887) and COVID-19 (GSE147507) were retrieved from the GEO database. After identifying the common differentially expressed genes (|log2FC| > 1 and adjusted P < 0.05), integrated analyses were performed, namely, enrichment analyses, protein-protein interacti

SUBMITTER: Zhang G 

PROVIDER: S-EPMC9349450 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature