Rapid and universal detection of SARS-CoV-2 and influenza A virus using a reusable dual-channel optic fiber immunosensor.

ABSTRACT: Establishment of rapid on-site detection technology capable of concurrently detecting SARS-Cov-2 and influenza A virus is urgent to effectively control the epidemic from these two types of important viruses. Accordingly, we developed a reusable dual-channel optical fiber immunosensor (DOFIS), which utilized the evanescent wave-sensing properties and tandem detection mode of the mobile phase, effectively accelerating the detection process such that it can be completed within 10 min. It could detect the nucleoprotein of multiple influenza A viruses (H1N1, H3N2, and H7N9), as well as the spike proteins of the SARS-CoV-2 Omicron and Delta variants, and could respond to 20 TCID₅₀ /ml SARS-CoV-2 pseudovirus and 100 TCID₅₀ /ml influenza A (A/PR/8/H1N1), presenting lower limi

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9349508 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature