Inflammation and vascular dysfunction: The negative synergistic combination of diabetes and COVID-19.

ABSTRACT:

Aims

Several reports indicate that diabetes determines an increased mortality risk in patients with coronavirus disease 19 (COVID-19) and a good glycaemic control appears to be associated with more favourable outcomes. Evidence also supports that COVID-19 pneumonia only accounts for a part of COVID-19 related deaths. This disease is indeed characterised by abnormal inflammatory response and vascular dysfunction, leading to the involvement and failure of different systems, including severe acute respiratory distress syndrome, coagulopathy, myocardial damage and renal failure. Inflammation and vascular dysfunction are also well-known features of hyperglycemia and diabetes, making up the ground for a detrimental synergistic combination that could explain the increased mortality observ

SUBMITTER: Bolla AM 

PROVIDER: S-EPMC9349661 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature