Impaired serological response to COVID-19 vaccination following anticancer therapy: A systematic review and meta-analysis.

ABSTRACT: Owing to the high coronavirus disease 2019 (COVID-19)-related morbidity and fatality rate among patients with cancer, the introduction of COVID-19 vaccines is of profound significance in this fragile population. Accumulating data suggested that oncologic patients, especially those with anticancer therapy have an impaired immune response to COVID-19 vaccination. However, the exact effect of anticancer treatments on postvaccination response has not been elucidated yet. We, therefore, conducted a meta-analysis to evaluate the impact of treatments on response to COVID-19 vaccination in patients with cancer. A total of 39 studies were finally included comprising 11 075 oncologic patients. Overall, we found the humoral response was significantly decreased in patients undergoing anticancer treatm

SUBMITTER: Tang K 

PROVIDER: S-EPMC9349696 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature