Thrombus formation during ECMO: Insights from a detailed histological analysis of thrombus composition.

ABSTRACT:

Objectives

Intra-device thrombosis remains one of the most common complications during extracorporeal membrane oxygenation (ECMO). Despite anticoagulation, approximately 35% of patients develop thrombi in the membrane oxygenator, pump heads, or tubing. The aim of this study was to describe the molecular and cellular features of ECMO thrombi and to study the main drivers of thrombus formation at different sites in the ECMO circuits.

Approach and results

Thrombi (n = 85) were collected immediately after veno-arterial-(VA)-ECMO circuit removal from 25 patients: 23 thrombi from the pump, 25 from the oxygenator, and 37 from the tubing. Quantitative histological analysis was performed for the amount of red blood cells (RBCs), platelets, fibrin, von Willebrand factor (VWF), leukocy

SUBMITTER: Staessens S 

PROVIDER: S-EPMC9349827 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature