Temporal changes in the accessory protein mutations of SARS-CoV-2 variants and their predicted structural and functional effects.

ABSTRACT: Emerging variants enable the continuous spread of SARS-CoV-2 in humans. The factors contributing to behavioral differences in variants remain elusive despite associations with several Spike protein mutations. Exploring accessory proteins may provide a wider understanding of these differences since these proteins may affect viral processes that occur beyond infection. Various bioinformatics tools were utilized to identify significant accessory protein mutations and determine their structural and functional effects over time. The ViruClust web application was used to retrieve accessory protein amino acid sequences and determine mutation frequencies in these sequences across time. The structural and functional effects of the mutations were determined using Missense3D and PROVEAN, respectively

SUBMITTER: Cruz CAK 

PROVIDER: S-EPMC9349927 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature