COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions.

ABSTRACT: We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID-19 patients.

SUBMITTER: Schrijver IT 

PROVIDER: S-EPMC9350042 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature