Real-World Experience Treating Pediatric Epilepsy Patients With Cenobamate.

ABSTRACT:

Introduction

In one third of all patients with epilepsy, seizure freedom is not achieved through anti-seizure medication (ASM). These patients have an increased risk of earlier death, poorer cognitive development, and reduced quality of life. Cenobamate (CNB) has recently been approved as a promising novel ASM drug for the treatment of adults with focal-onset epilepsy. However, there is little experience for its application in pediatric patients.

Methods

In a multicenter study we evaluated retrospectively the outcome of 16 pediatric patients treated "off label" with CNB.

Results

In 16 patients with a mean age of 15.38 years, CNB was started at an age of 15.05 years due to DRE. Prior to initiation of therapy, an average of 10.56 (range 3-20) ASM were prescribed. At ini

SUBMITTER: Makridis KL 

PROVIDER: S-EPMC9350548 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature