HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells.

ABSTRACT: HIV-1 replicates in CD4⁺ T cells, leading to AIDS. Determining how HIV-1 shapes its niche to create a permissive environment is central to informing efforts to limit pathogenesis, disturb reservoirs, and achieve a cure. A key roadblock in understanding HIV-T cell interactions is the requirement to activate T cells in vitro to make them permissive to infection. This dramatically alters T cell biology and virus-host interactions. Here we show that HIV-1 cell-to-cell spread permits efficient, productive infection of resting memory T cells without prior activation. Strikingly, we find that HIV-1 infection primes resting T cells to gain characteristics of tissue-resident memory T cells (T_RM), including upregulating key surface markers and the transcription factor Blimp-1 a

SUBMITTER: Reuschl AK 

PROVIDER: S-EPMC9350556 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature