Engineering living cells with cucurbit[7]uril-based supramolecular polymer chemistry: from cell surface engineering to manipulation of subcellular organelles.

ABSTRACT: Supramolecular polymer chemistry, which closely integrates noncovalent interactions with polymeric structures, is a promising toolbox for living cell engineering. Here, we report our recent progress in exploring the applications of cucurbit[7]uril (CB[7])-based supramolecular polymer chemistry for engineering living cells. First, a modular polymer-analogous approach was established to prepare multifunctional polymers that contain CB[7]-based supramolecular recognition motifs. The supramolecular polymeric systems were successfully applied to cell surface engineering and subcellular organelle manipulation. By anchoring polymers on the cell membranes, cell-cell interactions were established by CB[7]-based host-guest recognition, which further facilitated heterogeneous cell fusion. In addition

SUBMITTER: Huang F 

PROVIDER: S-EPMC9350592 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature