Therapeutic potential of dental pulp stem cells and their derivatives: Insights from basic research toward clinical applications.

ABSTRACT: For more than 20 years, researchers have isolated and identified postnatal dental pulp stem cells (DPSCs) from different teeth, including natal teeth, exfoliated deciduous teeth, healthy teeth, and diseased teeth. Their mesenchymal stem cell (MSC)-like immunophenotypic characteristics, high proliferation rate, potential for multidirectional differentiation and biological features were demonstrated to be superior to those of bone marrow MSCs. In addition, several main application forms of DPSCs and their derivatives have been investigated, including stem cell injections, modified stem cells, stem cell sheets and stem cell spheroids. In vitro and in vivo administration of DPSCs and their derivatives exhibited beneficial effects in various disease models of different tissues and

SUBMITTER: Yuan SM 

PROVIDER: S-EPMC9350620 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature