Analysis of Clinical Features, Diagnostic Tests, and Biomarkers in Patients With Suspected Creutzfeldt-Jakob Disease, 2014-2021.

ABSTRACT:

Importance

Detection of prion proteins in cerebrospinal fluid (CSF) using real-time quaking-induced conversion (RT-QuIC) assays has transformed the diagnostic approach to sporadic Creutzfeldt-Jakob disease (CJD), facilitating earlier and more complete recognition of affected patients. It is unclear how expanded recognition of affected patients may affect the diagnostic and prognostic relevance of clinical features and diagnostic tests historically associated with CJD.

Objective

To evaluate clinical features and diagnostic testing in patients presenting with CJD and determine the associations of these features with prognosis.

Design, setting, and participants

This cohort study incorporated data from electronic medical records of patients with CJD treated at Mayo Clinic

SUBMITTER: Shir D 

PROVIDER: S-EPMC9350714 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature