Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma.

ABSTRACT: The application of large-scale metabolomic profiling provides new opportunities for realizing the potential of omics-based precision medicine for asthma. By leveraging data from over 14,000 individuals in four distinct cohorts, this study identifies and independently replicates 17 steroid metabolites whose levels were significantly reduced in individuals with prevalent asthma. Although steroid levels were reduced among all asthma cases regardless of medication use, the largest reductions were associated with inhaled corticosteroid (ICS) treatment, as confirmed in a 4-year low-dose ICS clinical trial. Effects of ICS treatment on steroid levels were dose dependent; however, significant reductions also occurred with low-dose ICS treatment. Using information from electronic medical records, we

SUBMITTER: Kachroo P 

PROVIDER: S-EPMC9350737 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature