Three-month follow-up of durability of response to the third dose of the SARS-CoV-2 BNT162b2 vaccine in adults aged 60 years and older: a prospective cohort study.

ABSTRACT:

Objective

To evaluate the durability of response 3 months after the third BNT162b2 vaccine in adults aged 60 years and older.

Design

Prospective cohort study.

Setting

Single tertiary centre.

Participants

Healthcare workers/family members aged ≥60 years old who received the third BNT162b2 dose.

Interventions

Blood samples were drawn immediately before (T0), 10-19 days (T1) and 74-103 days (T2) after the third dose.

Primary and secondary outcome measures

Anti-spike IgG titres were determined using a commercial assay and seropositivity was defined as ≥50 arbitrary units (AU)/mL. Neutralising antibody titres were determined at T2. Adverse events, COVID-19 infections and Clinical Frailty Scale (CFS) levels were documented.

Results

The analysis i

SUBMITTER: Eliakim-Raz N 

PROVIDER: S-EPMC9350740 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature