Bronchoalveolar lavage cytokine patterns in children with severe neutrophilic and paucigranulocytic asthma.

ABSTRACT:

Background

Asthma is a complex heterogeneous disease occurring in adults and children that is characterized by distinct inflammatory patterns. While numerous studies have been performed in adults, little is known regarding the heterogeneity of severe asthma in children, particularly inflammatory signatures involving the air spaces.

Objective

We sought to determine the relationship of bronchoalveolar lavage (BAL) cytokine/chemokine expression patterns in children with severe therapy-resistant asthma stratified according to neutrophilic versus nonneutrophilic BAL inflammatory cell patterns.

Methods

Children with severe asthma with inadequate symptom control despite therapy underwent diagnostic bronchoscopy and BAL. Inflammatory cytokine/chemokine concentrations were det

SUBMITTER: Steinke JW 

PROVIDER: S-EPMC9350826 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature