Association of Oxidative Stress-Induced Nucleic Acid Damage With Psychiatric Disorders in Adults: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Nucleic acid damage from oxidative stress (NA-OXS) may be a molecular mechanism driving the severely increased morbidity and mortality from somatic causes in adults with psychiatric disorders.

Objective

To systematically retrieve and analyze data on NA-OXS across the psychiatric disorder diagnostic spectrum.

Data sources

The PubMed, Embase, and PsycINFO databases were searched from inception to November 16, 2021. A hand search of reference lists of relevant articles was also performed.

Study selection

Key study inclusion criteria in this meta-analysis were as follows: adult human study population, measurement of any marker of DNA or RNA damage from oxidative stress, and either a (1) cross-sectional design comparing patients with psychiatric disorders

SUBMITTER: Jorgensen A 

PROVIDER: S-EPMC9350850 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature