Exercise and the Risk of Mild Cognitive Impairment: Does the Effect Depend on Vascular Factors?

ABSTRACT:

Introduction

Although exercise is associated with a lower risk for mild cognitive impairment (MCI), it is unclear whether its protective effect depends on the presence or absence of vascular factors.

Methods

In an exploratory study of data from a population-based cohort, 1254 participants aged 65+ years were followed for 10 years for incident MCI. The main effect of baseline total minutes of exercise per week (0 vs. 1 to 149 vs. 150+), and its interaction with several vascular factors, on risk for incident MCI was examined using Cox proportional hazards regression models, adjusting for demographics.

Results

Compared with no exercise, 1 to 149 minutes [hazard ratio (HR)=0.90; 95% confidence interval (95% CI), 0.69-1.16] and 150 or more minutes per week (HR=0.84; 95% CI

SUBMITTER: Hughes TF 

PROVIDER: S-EPMC9350907 | biostudies-literature | 2021 Jan-Mar 01

REPOSITORIES: biostudies-literature