Genetic variation within the human papillomavirus type 16 genome is associated with oropharyngeal cancer prognosis.

ABSTRACT:

Purpose

A significant barrier to adoption of de-escalated treatment protocols for human papillomavirus-driven oropharyngeal cancer (HPV-OPC) is that few predictors of poor prognosis exist. We conducted the first large whole-genome sequencing (WGS) study to characterize the genetic variation of the HPV type 16 (HPV16) genome and to evaluate its association with HPV-OPC patient survival.

Patients and methods

A total of 460 OPC tumor specimens from two large United States medical centers (1980-2017) underwent HPV16 whole-genome sequencing. Site-specific variable positions [single nucleotide polymorphisms (SNPs)] across the HPV16 genome were identified. Cox proportional hazards model estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival by HPV16 S

SUBMITTER: Lang Kuhs KA 

PROVIDER: S-EPMC9350957 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature