Modeling early changes associated with cartilage trauma using human-cell-laden hydrogel cartilage models.

ABSTRACT:

Background

Traumatic impacts to the articular joint surface are known to lead to cartilage degeneration, as in post-traumatic osteoarthritis (PTOA). Limited progress in the development of disease-modifying OA drugs (DMOADs) may be due to insufficient mechanistic understanding of human disease onset/progression and insufficient in vitro models for disease and therapeutic modeling. In this study, biomimetic hydrogels laden with adult human mesenchymal stromal cells (MSC) are used to examine the effects of traumatic impacts as a model of PTOA. We hypothesize that MSC-based, engineered cartilage models will respond to traumatic impacts in a manner congruent with early PTOA pathogenesis observed in animal models.

Methods

Engineered cartilage constructs were fabricated by encapsul

SUBMITTER: He C 

PROVIDER: S-EPMC9351070 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature