Functional reorganization of monoamine transport systems during villous trophoblast differentiation: evidence of distinct differences between primary human trophoblasts and BeWo cells.

ABSTRACT:

Background

Three primary monoamines-serotonin, norepinephrine, and dopamine-play major roles in the placenta-fetal brain axis. Analogously to the brain, the placenta has transport mechanisms that actively take up these monoamines into trophoblast cells. These transporters are known to play important roles in the differentiated syncytiotrophoblast layer, but their status and activities in the undifferentiated, progenitor cytotrophoblast cells are not well understood. Thus, we have explored the cellular handling and regulation of monoamine transporters during the phenotypic transitioning of cytotrophoblasts along the villous pathway.

Methods

Experiments were conducted with two cellular models of syncytium development: primary trophoblast cells isolated from the human term plac

SUBMITTER: Vachalova V 

PROVIDER: S-EPMC9351077 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature