Landscape of lipidomic metabolites in gut-liver axis of Sprague-Dawley rats after oral exposure to titanium dioxide nanoparticles.

ABSTRACT:

Background

The application of titanium dioxide nanoparticles (TiO₂ NPs) as food additives poses a risk of oral exposure that may lead to adverse health effects. Even though the substantial evidence supported liver as the target organ of TiO₂ NPs via oral exposure, the mechanism of liver toxicity remains largely unknown. Since the liver is a key organ for lipid metabolism, this study focused on the landscape of lipidomic metabolites in gut-liver axis of Sprague Dawley (SD) rats exposed to TiO₂ NPs at 0, 2, 10, 50 mg/kg body weight per day for 90 days.

Results

TiO₂ NPs (50 mg/kg) caused slight hepatotoxicity and changed lipidomic signatures of main organs or systems in the gut-liver axis including liver, serum and gut. The cluster pr

SUBMITTER: Chen Z 

PROVIDER: S-EPMC9351087 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature