Ontology highlight
ABSTRACT:
SUBMITTER: Zhu C
PROVIDER: S-EPMC9351107 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Zhu Chunxiao C Guan Xiaoqing X Zhang Xinuo X Luan Xin X Song Zhengbo Z Cheng Xiangdong X Zhang Weidong W Qin Jiang-Jiang JJ
Molecular cancer 20220804 1
Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is the most frequently mutated oncogene, occurring in a variety of tumor types. Targeting KRAS mutations with drugs is challenging because KRAS is considered undruggable due to the lack of classic drug binding sites. Over the past 40 years, great efforts have been made to explore routes for indirect targeting of KRAS mutant cancers, including KRAS expression, processing, upstream regulators, or downstream effectors. With the advent of KRAS (G12C) ...[more]