Viral dynamics and immune responses to foot-and-mouth disease virus in African buffalo (Syncerus caffer).

ABSTRACT: Foot-and-mouth disease (FMD) is one of the most important livestock diseases restricting international trade. While African buffalo (Syncerus caffer) act as the main wildlife reservoir, viral and immune response dynamics during FMD virus acute infection have not been described before in this species. We used experimental needle inoculation and contact infections with three Southern African Territories serotypes to assess clinical, virological and immunological dynamics for thirty days post infection. Clinical FMD in the needle inoculated buffalo was mild and characterised by pyrexia. Despite the absence of generalised vesicles, all contact animals were readily infected with their respective serotypes within the first two to nine days after being mixed with needle challenged buffalo. Irresp

SUBMITTER: Perez-Martin E 

PROVIDER: S-EPMC9351118 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature