Association between metabolic syndrome, C-reactive protein, and the risk of primary liver cancer: a large prospective study.

ABSTRACT:

Background and aims

High-sensitivity C-reactive protein (hs-CRP) levels and metabolic syndrome (MetS) are known to be associated with an increased incidence of different cancers. We aimed to evaluate the effect of MetS combined with high hs-CRP levels on the risk of primary liver cancer (PLC).

Methods

Participants were recruited from the Kailuan cohort study and were classified into four groups according to the presence or absence of MetS and inflammation (hs-CRP ≥ 3 or < 3 mg/L). The associations of MetS and inflammation with the risk of PLC were assessed using Cox proportional hazards models.

Results

This study included 92,770 participants. The mean age was 51.4 years old. Over a median follow-up of 13.02 years, 395 participants were diagnosed as PLC. Compared to th

SUBMITTER: Song M 

PROVIDER: S-EPMC9351132 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature