Role of adipose tissue-derived cytokines in the progression of inflammatory breast cancer in patients with obesity.

ABSTRACT:

Background

Inflammatory breast cancer (IBC) represents a deadly aggressive phenotype of breast cancer (BC) with a unique clinicopathological presentation and low survival rate. In fact, obesity represents an important risk factor for BC. Although several studies have identified different cellular-derived and molecular factors involved in IBC progression, the role of adipocytes remains unclear. Cancer-associated adipose tissue (CAAT) expresses a variety of adipokines, which contribute to tumorigenesis and the regulation of cancer stem cell (CSC). This research investigated the potential effect of the secretome of CAAT explants from patients with BC on the progression and metastasis of the disease.

Methods

This study established an ex-vivo culture of CAAT excised from IBC (n =

SUBMITTER: Ibrahim AS 

PROVIDER: S-EPMC9351154 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature