The impacts of viral infection and subsequent antimicrobials on the microbiome-resistome of growing pigs.

ABSTRACT:

Background

Antimicrobials are used in food-producing animals for purposes of preventing, controlling, and/or treating infections. In swine, a major driver of antimicrobial use is porcine reproductive and respiratory syndrome (PRRS), which is caused by a virus that predisposes infected animals to secondary bacterial infections. Numerous antimicrobial protocols are used to treat PRRS, but we have little insight into how these treatment schemes impact antimicrobial resistance (AMR) dynamics within the fecal microbiome of commercial swine. The aim of this study was to determine whether different PRRS-relevant antimicrobial treatment protocols were associated with differences in the fecal microbiome and resistome of growing pigs. To accomplish this, we used a metagenomics approach to ch

SUBMITTER: Gaire TN 

PROVIDER: S-EPMC9351240 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature