Le Cœur en Sabot: shape associations with adverse events in repaired tetralogy of Fallot.

ABSTRACT:

Background

Maladaptive remodelling mechanisms occur in patients with repaired tetralogy of Fallot (rToF) resulting in a cycle of metabolic and structural changes. Biventricular shape analysis may indicate mechanisms associated with adverse events independent of pulmonary regurgitant volume index (PRVI). We aimed to determine novel remodelling patterns associated with adverse events in patients with rToF using shape and function analysis.

Methods

Biventricular shape and function were studied in 192 patients with rToF (median time from TOF repair to baseline evaluation 13.5 years). Linear discriminant analysis (LDA) and principal component analysis (PCA) were used to identify shape differences between patients with and without adverse events. Adverse events included death, arr

SUBMITTER: Mira A 

PROVIDER: S-EPMC9351245 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature